RT Generic T1 Response. A1 Javaheri, Shahrokh A1 Campos-Rodriguez, Francisco A1 Martinez-Garcia, Miguel Angel K1 Continuous positive airway pressure K1 Propensity score analysis K1 Randomized controlled trial K1 Cardiovascular disease K1 Sleep apnea, obstructive K1 Observational study AB We read with interest the letter from Singh et al proposing a two-stage propensity score PS analysis as an alternative method to include sleepy patients in a trial that explores the relation between CPAP treatment and the prevention of cardiovascular diseases In our commentary 1 we only addressed the topic of randomized controlled trials RCTs with the aim of providing potentially useful suggestions to conduct future trials to overcome the challenges that RCTs involve We deliberately did not focus on observational trials or those using PS analysis PB American College of Chest Physicians YR 2020 FD 2020 LK http://hdl.handle.net/10668/15329 UL http://hdl.handle.net/10668/15329 LA en NO Javaheri S, Campos-Rodriguez F, Martinez-Garcia MA. Response. Chest. 2020 Apr;157(4):1047-1048 DS RISalud RD Aug 12, 2025