RT Journal Article
T1 Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registry
A1 Navas Alcantara, Maria Sierra
A1 Montero Rivas, Lorena
A1 Guisado Espartero, Maria Esther
A1 Rubio-Rivas, Manuel
A1 Ayuso Garcia, Blanca
A1 Moreno Martinez, Francisco
A1 Ausin Garcia, Cristina
A1 Taboada Martinez, Maria Luisa
A1 Arnalich Fernandez, Francisco
A1 Martinez Murgui, Raul
A1 Molinos Castro, Sonia
A1 Ramos Munoz, Maria Esther
A1 Fernandez-Garces, Mar
A1 Carreno Hernandez, Mari Cruz
A1 Garcia Garcia, Gema Maria
A1 Vazquez Piqueras, Nuria
A1 Abadia-Otero, Jesica
A1 Lajara Villar, Lourdes
A1 Salazar Monteiro, Cristina
A1 Pascual Perez, Maria de los Reyes
A1 Perez-Martin, Santiago
A1 Collado-Aliaga, Javier
A1 Anton-Santos, Juan-Miguel
A1 Lumbreras-Bermejo, Carlos
A1 SEMI-COVID-19, 
K1 COVID-19
K1 SARS-CoV-2
K1 Smoking
K1 Mortality
K1 Hospitalized
AB Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.(c) 2021 Elsevier Espana, S.L.U. All rights reserved.
PB Elsevier espana slu
SN 0025-7753
YR 2022
FD 2022-08-30
LK https://hdl.handle.net/10668/26655
UL https://hdl.handle.net/10668/26655
LA en
DS RISalud
RD Apr 17, 2025