%0 Journal Article
%A Navas Alcantara, Maria Sierra
%A Montero Rivas, Lorena
%A Guisado Espartero, Maria Esther
%A Rubio-Rivas, Manuel
%A Ayuso Garcia, Blanca
%A Moreno Martinez, Francisco
%A Ausin Garcia, Cristina
%A Taboada Martinez, Maria Luisa
%A Arnalich Fernandez, Francisco
%A Martinez Murgui, Raul
%A Molinos Castro, Sonia
%A Ramos Munoz, Maria Esther
%A Fernandez-Garces, Mar
%A Carreno Hernandez, Mari Cruz
%A Garcia Garcia, Gema Maria
%A Vazquez Piqueras, Nuria
%A Abadia-Otero, Jesica
%A Lajara Villar, Lourdes
%A Salazar Monteiro, Cristina
%A Pascual Perez, Maria de los Reyes
%A Perez-Martin, Santiago
%A Collado-Aliaga, Javier
%A Anton-Santos, Juan-Miguel
%A Lumbreras-Bermejo, Carlos
%A SEMI-COVID-19
%T Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registry
%D 2022
%@ 0025-7753
%U https://hdl.handle.net/10668/26655
%X Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.(c) 2021 Elsevier Espana, S.L.U. All rights reserved.
%K COVID-19
%K SARS-CoV-2
%K Smoking
%K Mortality
%K Hospitalized
%~