RT Journal Article
T1 Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance-Supercontrollers.
A1 Dominguez-Molina, Beatriz
A1 Ferrando-Martinez, Sara
A1 Tarancon-Diez, Laura
A1 Hernandez-Quero, Jose
A1 Genebat, Miguel
A1 Vidal, Francisco
A1 Muñoz-Fernandez, Mª Angeles
A1 Leal, Manuel
A1 Koup, Richard
A1 Ruiz-Mateos, Ezequiel
K1 HCV
K1 HIV
K1 NK
K1 T-cells
K1 controllers
K1 pDCs
K1 spontaneous clearance
K1 supercontrollers
AB HIV-elite controllers are a minority group of HIV-infected patients with the ability to maintain undetectable HIV viremia for long time periods without antiretroviral treatment. A small group of HIV-controllers are also able to spontaneously clear the hepatitis C virus (HCV) whom we can refer to as "supercontrollers." There are no studies that explore immune correlates looking for the mechanisms implicated in this extraordinary phenomenon. Herein, we have analyzed HCV- and HIV-specific T-cell responses, as well as T, dendritic and NK cell phenotypes. The higher HCV-specific CD4 T-cell polyfunctionality, together with a low activation and exhaustion T-cell phenotype was found in supercontrollers. In addition, the frequency of CD8 CD161high T-cells was related with HIV- and HCV-specific T-cells polyfunctionality. Interesting features regarding NK and plasmacytoid dendritic cells (pDCs) were found. The study of the supercontroller's immune response, subjects that spontaneously controls both chronic viral infections, could provide further insights into virus-specific responses needed to develop immunotherapeutic strategies in the setting of HIV cure or HCV vaccination.
YR 2018
FD 2018-12-10
LK http://hdl.handle.net/10668/13390
UL http://hdl.handle.net/10668/13390
LA en
DS RISalud
RD Apr 4, 2025