TY  - JOUR
AU  - Medina-Carmona, Encarnación
AU  - Palomino-Morales, Rogelio J
AU  - Fuchs, Julian E
AU  - Padín-Gonzalez, Esperanza
AU  - Mesa-Torres, Noel
AU  - Salido, Eduardo
AU  - Timson, David J
AU  - Pey, Angel L
PY  - 2016
DO  - 10.1038/srep20331
UR  - http://hdl.handle.net/10668/9803
T2  - Scientific reports
AB  - Protein dynamics is essential to understand protein function and stability, even though is rarely investigated as the origin of loss-of-function due to genetic variations. Here, we use biochemical, biophysical, cell and computational biology tools to...
LA  - en
KW  - Binding Sites
KW  - Caco-2 Cells
KW  - Crystallography, X-Ray
KW  - Dicumarol
KW  - Enzyme Stability
KW  - Flavin-Adenine Dinucleotide
KW  - HCT116 Cells
KW  - HeLa Cells
KW  - Humans
KW  - NAD(P)H Dehydrogenase (Quinone)
KW  - Neoplasms
KW  - Polymorphism, Single Nucleotide
KW  - Protein Binding
KW  - Protein Conformation
KW  - Protein Multimerization
TI  - Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.
TY  - research article
VL  - 6
ER  -