TY - JOUR AU - Álvarez-Quilón, Alejandro AU - Terrón-Bautista, José AU - Delgado-Sainz, Irene AU - Serrano-Benítez, Almudena AU - Romero-Granados, Rocío AU - Martínez-García, Pedro Manuel AU - Jimeno-González, Silvia AU - Bernal-Lozano, Cristina AU - Quintero, Cristina AU - García-Quintanilla, Lourdes AU - Cortés-Ledesma, Felipe PY - 2020 DO - 10.1038/s41467-020-14638-w UR - http://hdl.handle.net/10668/15110 T2 - Nature communications AB - The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T... LA - en KW - Animals KW - Ataxia Telangiectasia Mutated Proteins KW - DNA Breaks, Double-Stranded KW - DNA Repair KW - DNA Topoisomerases, Type II KW - DNA-Binding Proteins KW - Humans KW - Mice KW - Mice, Knockout KW - Phosphoric Diester Hydrolases KW - Thymus Neoplasms TI - Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency. TY - research article VL - 11 ER -