RT Journal Article
T1 Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
A1 Ruiz-Canela, Miguel
A1 Toledo, Estefania
A1 Clish, Clary B
A1 Hruby, Adela
A1 Liang, Liming
A1 Salas-Salvadó, Jordi
A1 Razquin, Cristina
A1 Corella, Dolores
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Fitó, Montserrat
A1 Gómez-Gracia, Enrique
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Lapetra, José
A1 Serra-Majem, Lluis
A1 Martínez-González, Miguel A
A1 Hu, Frank B
AB The role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. We developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. After adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. Higher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
YR 2016
FD 2016-02-17
LK http://hdl.handle.net/10668/9846
UL http://hdl.handle.net/10668/9846
LA en
DS RISalud
RD Apr 9, 2025