RT Journal Article
T1 High adherence to the Western, Prudent, and Mediterranean dietary patterns and risk of gastric adenocarcinoma: MCC-Spain study.
A1 Castelló, Adela
A1 Fernández de Larrea, Nerea
A1 Martín, Vicente
A1 Dávila-Batista, Verónica
A1 Boldo, Elena
A1 Guevara, Marcela
A1 Moreno, Víctor
A1 Castaño-Vinyals, Gemma
A1 Gómez-Acebo, Inés
A1 Fernández-Tardón, Guillermo
A1 Peiró, Rosana
A1 Olmedo-Requena, Rocío
A1 Capelo, Rocio
A1 Navarro, Carmen
A1 Pacho-Valbuena, Silvino
A1 Pérez-Gómez, Beatriz
A1 Kogevinas, Manolis
A1 Pollán, Marina
A1 Aragonés, Nuria
A1 MCC-Spain researchers, 
K1 Adenocarcinoma
K1 Diet, Mediterranean
K1 Diet, Western
K1 Population attributable fraction
K1 Prevention and control
K1 Principal component analysis
K1 Stomach neoplasms
AB The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology. MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age. Risk according to tumor site (cardia, non-cardia) and morphology (intestinal/diffuse) was evaluated using multinomial regression models. A high adherence to the Western pattern increased gastric adenocarcinoma risk [odds ratiofourth_vs._first_quartile (95% confidence interval), 2.09 (1.31; 3.33)] even at low levels [odds ratiosecond_vs._first_quartile (95% confidence interval), 1.63 (1.05; 2.52)]. High adherence to the Mediterranean dietary pattern could prevent gastric adenocarcinoma [odds ratiofourth_vs._first_quartile (95% confidence interval), 0.53 (0.34; 0.82)]. Although no significant heterogeneity of effects was observed, the harmful effect of the Western pattern was stronger among older participants and for non-cardia adenocarcinomas, whereas the protective effect of the Mediterranean pattern was only observed among younger participants and for non-cardia tumors. Decreasing the consumption of fatty and sugary products and of red and processed meat in favor of an increase in the intake of fruits, vegetables, legumes, olive oil, nuts, and fish might prevent gastric adenocarcinoma.
YR 2017
FD 2017-11-14
LK http://hdl.handle.net/10668/11801
UL http://hdl.handle.net/10668/11801
LA en
DS RISalud
RD Apr 7, 2025