%0 Journal Article
%A Ceausu, Andra
%A Rodríguez-Gallego, Esther
%A Peraire, Joaquim
%A López-Dupla, Miguel
%A Domingo, Pere
%A Viladés, Consuelo
%A Vidal-Gonzalez, Judit
%A Peraire, Maria
%A Perpiñán, Carles
%A Pacheco, Yolanda María
%A Veloso, Sergi
%A Alba, Verónica
%A Vargas, Montserrat
%A Castellano, Alfonso J
%A Ruiz-Mateos, Ezequiel
%A Mallolas, Josep
%A Vidal, Francesc
%A Rull, Anna
%T IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status.
%D 2019
%U http://hdl.handle.net/10668/14616
%X A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.
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