%0 Journal Article
%A Escamilla Gómez, Virginia
%A García-Gutiérrez, Valentín
%A López Corral, Lucía
%A García Cadenas, Irene
%A Pérez Martínez, Ariadna
%A Márquez Malaver, Francisco J
%A Caballero-Velázquez, Teresa
%A González Sierra, Pedro A
%A Viguria Alegría, María C
%A Parra Salinas, Ingrid M
%A Calderón Cabrera, Cristina
%A González Vicent, Marta
%A Rodríguez Torres, Nancy
%A Parody Porras, Rocío
%A Ferra Coll, Christelle
%A Orti, Guillermo
%A Valcárcel Ferreiras, David
%A De la Cámara LLanzá, Rafael
%A Molés, Paula
%A Velázquez-Kennedy, Kyra
%A João Mende, María
%A Caballero Barrigón, Dolores
%A Pérez, Estefanía
%A Martino Bofarull, Rodrigo
%A Saavedra Gerosa, Silvanna
%A Sierra, Jorge
%A Poch, Marc
%A Zudaire Ripa, María T
%A Díaz Pérez, Miguel A
%A Molina Angulo, Blanca
%A Sánchez Ortega, Isabel
%A Sanz Caballer, Jaime
%A Montoro Gómez, Juan
%A Espigado Tocino, Ildefonso
%A Pérez-Simón, José A
%A Grupo Español de Trasplante Hematopoyético (GETH)
%T Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study.
%D 2019
%U http://hdl.handle.net/10668/14653
%X Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients.
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