RT Journal Article
T1 Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort.
A1 Fages, Anne
A1 Duarte-Salles, Talita
A1 Stepien, Magdalena
A1 Ferrari, Pietro
A1 Fedirko, Veronika
A1 Pontoizeau, Clément
A1 Trichopoulou, Antonia
A1 Aleksandrova, Krasimira
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Clavel-Chapelon, Françoise
A1 Boutron-Ruault, Marie-Christine
A1 Severi, Gianluca
A1 Kaaks, Rudolf
A1 Kuhn, Tilman
A1 Floegel, Anna
A1 Boeing, Heiner
A1 Lagiou, Pagona
A1 Bamia, Christina
A1 Trichopoulos, Dimitrios
A1 Palli, Domenico
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Bueno-de-Mesquita, H Bas
A1 Peeters, Petra H
A1 Weiderpass, Elisabete
A1 Agudo, Antonio
A1 Molina-Montes, Esther
A1 Huerta, José María
A1 Ardanaz, Eva
A1 Dorronsoro, Miren
A1 Sjöberg, Klas
A1 Ohlsson, Bodil
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Travis, Ruth C
A1 Schmidt, Julie A
A1 Cross, Amanda
A1 Gunter, Marc
A1 Riboli, Elio
A1 Scalbert, Augustin
A1 Romieu, Isabelle
A1 Elena-Herrmann, Benedicte
A1 Jenab, Mazda
K1 Epidemiology
K1 European Prospective Investigation into Cancer and Nutrition
K1 Hepatocellular carcinoma
K1 Liver cancer
K1 Metabolomics
K1 Nuclear magnetic resonance
K1 Carcinoma Hepatocelular
K1 Neoplasias Hepáticas
K1 Metabolómica
K1 Estudios Prospectivos
AB BACKGROUNDHepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers.METHODSTo address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort.RESULTSA metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis.CONCLUSIONOur results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer.
PB BioMed Central
YR 2015
FD 2015-09-23
LK http://hdl.handle.net/10668/2102
UL http://hdl.handle.net/10668/2102
LA spa
NO Fages A, Duarte-Salles T, Stepien M, Ferrari P, Fedirko V, Pontoizeau C, et al. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort. BMC Med 2015;13(1):242
NO JOURNAL ARTICLE;
DS RISalud
RD Apr 12, 2025