RT Journal Article T1 Sars-Cov-2 Infection in Patients on Long-Term Treatment with Macrolides in Spain: A National Cross-Sectional Study. A1 Meseguer Barros, Carmen Marina A1 Alzueta Isturiz, Natalia A1 Sainz de Rozas Aparicio, Rita A1 Vizcaíno, Rafael Aguilella A1 López Esteban, Laura A1 Anaya Ordóñez, Sonia A1 Lekue Alkorta, Itxasne A1 Martín Suances, Salvadora A1 Jiménez Arce, Jorge Ignacio A1 Fernández Vicente, Maite A1 Borrego Izquierdo, Yolanda A1 Prieto Sánchez, Raquel A1 Casado Casuso, Silvia A1 Madridejos, Rosa A1 Verde, Carmen Marquina A1 Tomás Sanz, Rosa A1 Oro Fernández, María A1 Gallardo Borge, Sara A1 Lázaro López, Eva A1 Pina Gadea, María Belén A1 Pereira Pía, Mercedes A1 Maestre-Sánchez, María Victoria A1 Ribes-Murillo, Esther A1 Gómez de Oña, Constanza A1 María Jesús Lallana, Álvarez A1 Celaya Lecea, Concepción A1 Prado Prieto, María Ana A1 Aranguez Ruiz, Aranzazu A1 Olmo Quintana, Vicente A1 Villén Romero, Noemí A1 Payá Giner, Carolina A1 Lloret Callejo, Angeles A1 Fernández Ferreiro, Alvaro A1 Basagoiti Carreño, Blanca A1 Iglesias Iglesias, Ana Aurelia A1 Martín Alonso, Antonio A1 Díez Alcántara, Ana A1 Marco Tejón, Esther A1 Lestón Vázquez, Marta A1 Ariza Copado, Mª Ángeles A1 Aparicio Cueva, Marta A1 Escudero Vilaplana, Belén A1 Nicieza, Marisa A1 Picazo Sanchiz, Gracia A1 Silva Riádigos, Genma María A1 Sánchez, Lucía Jamart A1 García Álvarez, Ángel A1 García Bonilla, Antonio A1 Herrero Delicado, Rafael A1 Arroyo Pineda, Virginia A1 de la Hija, Belén A1 Troncoso Mariño, Amelia A1 Tofiño González, Isabel A1 Mateu García, Mónica Susana A1 García Vázquez, Pablo A1 Pérez Martín, Joaquín A1 Fernández-Urrusuno, Rocío K1 COVID-19 K1 SARS-CoV-2 K1 ambulatory care K1 azithromycin K1 long-term treatment K1 macrolides K1 outpatients AB The aim of this study was to know the prevalence and severity of COVID-19 in patients treated with long-term macrolides and to describe the factors associated with worse outcomes. A cross-sectional study was conducted in Primary Care setting. Patients with macrolides dispensed continuously from 1 October 2019 to 31 March 2020, were considered. Main outcome: diagnosis of coronavirus disease-19 (COVID-19). Secondary outcomes: symptoms, severity, characteristics of patients, comorbidities, concomitant treatments. A total of 3057 patients met the inclusion criteria. Median age: 73 (64-81) years; 55% were men; 62% smokers/ex-smokers; 56% obese/overweight. Overall, 95% of patients had chronic respiratory diseases and four comorbidities as a median. Prevalence of COVID-19: 4.8%. This was in accordance with official data during the first wave of the pandemic. The most common symptoms were respiratory: shortness of breath, cough, and pneumonia. Additionally, 53% percent of patients had mild/moderate symptoms, 28% required hospital admission, and 19% died with COVID-19. The percentage of patients hospitalized and deaths were 2.6 and 5.8 times higher, respectively, in the COVID-19 group (p SN 2079-6382 YR 2021 FD 2021-08-25 LK https://hdl.handle.net/10668/24734 UL https://hdl.handle.net/10668/24734 LA en DS RISalud RD Apr 11, 2025