RT Journal Article
T1 The Combined Intervention with Germinated Vigna radiata and Aerobic Interval Training Protocol Is an Effective Strategy for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Alterations Related to the Metabolic Syndrome in Zucker Rats.
A1 Kapravelou, Garyfallia
A1 Martínez, Rosario
A1 Nebot, Elena
A1 López-Jurado, María
A1 Aranda, Pilar
A1 Arrebola, Francisco
A1 Cantarero, Samuel
A1 Galisteo, Milagros
A1 Porres, Jesus M
K1 Vigna radiata
K1 aerobic interval training
K1 diet
K1 exercise
K1 germination
K1 legume protein hydrolyzate
K1 liver histology
K1 metabolic syndrome
K1 non-alcoholic fatty liver disease
K1 obesity
AB Metabolic syndrome (MetS) is a group of related metabolic alterations that increase the risk of developing non-alcoholic fatty liver disease (NAFLD). Several lifestyle interventions based on dietary treatment with functional ingredients and physical activity are being studied as alternative or reinforcement treatments to the pharmacological ones actually in use. In the present experiment, the combined treatment with mung bean (Vigna radiata), a widely used legume with promising nutritional and health benefits that was included in the experimental diet as raw or 4 day-germinated seed flour, and aerobic interval training protocol (65-85% VO₂ max) has been tested in lean and obese Zucker rats following a 2 × 2 × 2 (2 phenotypes, 2 dietary interventions, 2 lifestyles) factorial ANOVA (Analysis of Variance) statistical analysis. Germination of V. radiata over a period of four days originated a significant protein hydrolysis leading to the appearance of low molecular weight peptides. The combination of 4 day-germinated V. radiata and aerobic interval training was more efficient compared to raw V. radiata at improving the aerobic capacity and physical performance, hepatic histology and functionality, and plasma lipid parameters as well as reverting the insulin resistance characteristic of the obese Zucker rat model. In conclusion, the joint intervention with legume sprouts and aerobic interval training protocol is an efficient treatment to improve the alterations of glucose and lipid metabolism as well as hepatic histology and functionality related to the development of NAFLD and the MetS.
YR 2017
FD 2017-07-19
LK http://hdl.handle.net/10668/11450
UL http://hdl.handle.net/10668/11450
LA en
DS RISalud
RD Apr 7, 2025