RT Journal Article T1 Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. A1 Álvarez-Zaballos, Sara A1 González-Ramallo, Victor A1 Quintana, Eduard A1 Muñoz, Patricia A1 de la Villa-Martínez, Sofía A1 Fariñas, M Carmen A1 Arnáiz-de Las Revillas, Francisco A1 de Alarcón, Arístides A1 Rodríguez-Esteban, M Ángeles A1 Miró, José M A1 Goenaga, Miguel Angel A1 Goikoetxea-Agirre, Josune A1 García-Vázquez, Elisa A1 Boix-Palop, Lucía A1 Martínez-Sellés, Manuel A1 On Behalf Of Games, K1 infective endocarditis K1 mortality K1 multivalvular endocarditis K1 prognosis AB Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p SN 2077-0383 YR 2022 FD 2022-08-13 LK http://hdl.handle.net/10668/21333 UL http://hdl.handle.net/10668/21333 LA en DS RISalud RD Apr 9, 2025