RT Journal Article
T1 The CRAS-EAHFE study: Characteristics and prognosis of acute heart failure episodes with cardiorenal-anaemia syndrome at the emergency department.
A1 Llauger, Lluis
A1 Jacob, Javier
A1 Herrero-Puente, Pablo
A1 Aguirre, Alfons
A1 Suñén-Cuquerella, Guillem
A1 Corominas-Lasalle, Gerard
A1 Llorens, Pere
A1 Martín-Sánchez, Francisco J
A1 Gil, Víctor
A1 Roset, Alex
A1 Ruibal, José C
A1 Pérez-Durá, María J
A1 Juan-Gómez, María Á
A1 Garrido, José M
A1 Richard, Fernando
A1 Lucas-Imbernon, Francisco J
A1 Alonso, Héctor
A1 Tost, Josep
A1 Gil, Cristina
A1 Miró, Òscar
A1 ICA-SEMES Research Group, 
K1 Acute heart failure
K1 anaemia
K1 cardiorenal-anaemia syndrome
K1 mortality
K1 reconsultation
K1 renal insufficiency
AB The coexistence of other comorbidities confers poor outcomes in patients with acute heart failure. Our aim was to determine the characteristics of patients with acute heart failure and cardiorenal anaemia syndrome and the relationship between renal dysfunction and anaemia, alone or combined as cardiorenal anaemia syndrome, on short-term outcomes. We analysed the Epidemiology of Acute Heart Failure in Emergency Departments registry (cohort of patients with acute heart failure in Spanish emergency departments). Renal dysfunction was defined by an estimated glomerular filtration rate 10 days), in-hospital mortality during the index event, and reconsultation and the combination of 30-day post-discharge reconsultation/death. These short-term outcomes were compared and adjusted for differences among groups. Of the 13,307 patients analysed, CRAS+ (36.4%) was associated with older age, multiple comorbidities, chronic use of loop diuretics, oedemas and hypotension. The 30-day mortality in CRAS+ was greater than in CRAS- (hazard ratio = 1.46, 95% confidence interval = 1.26-1.68) and RD-/A- (hazard ratio = 1.83, 95% confidence interval = 1.46-2.28) control groups. The mortality level was also higher in RD+/A- (hazard ratio = 1.40, 95% confidence interval = 1.10-1.78) and higher, but not statistically significant, in RD-/A+ (hazard ratio = 1.28, 95% confidence interval = 0.99-1.63) with respect to RD-/A-. All of the secondary outcomes, when related to CRAS- and RD-/A- control groups, were worse for CRAS+ and to a lesser extent, RD+/A-, being more rarely observed in RD-/A+. Cardiorenal anaemia syndrome in acute heart failure is related to greater mortality and worse short-term outcomes, and the impact of renal dysfunction and anaemia seems to be additive.
YR 2020
FD 2020-05-14
LK https://hdl.handle.net/10668/27713
UL https://hdl.handle.net/10668/27713
LA en
DS RISalud
RD Apr 17, 2025