TY - JOUR AU - Florido, Javier AU - Martinez-Ruiz, Laura AU - Rodriguez-Santana, Cesar AU - Lopez-Rodriguez, Alba AU - Hidalgo-Gutierrez, Agustin AU - Cottet-Rousselle, Cecile AU - Lamarche, Frederic AU - Schlattner, Uwe AU - Guerra-Librero, Ana AU - Aranda-Martinez, Paula AU - Acuña-Castroviejo, Darío AU - Lopez, Luis C AU - Escames, Germaine PY - 2022 DO - 10.1111/jpi.12824 UR - http://hdl.handle.net/10668/20000 T2 - Journal of pineal research AB - The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS) levels, but how melatonin induces this ROS generation is unknown. In the present study, we aimed to elucidate the two seemingly opposing actions of melatonin... LA - en PB - Wiley-Blackwell Publishing, Inc. KW - apoptosis KW - head and neck cancer cells KW - melatonin KW - mitochondria KW - oxidative damage KW - reactive oxygen species KW - reverse electron transport KW - Animals KW - Apoptosis KW - Electron Transport KW - Head and Neck Neoplasms KW - Humans KW - Melatonin KW - Mice KW - Reactive Oxygen Species TI - Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport. TY - research article VL - 73 ER -