RT Journal Article
T1 Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa
A1 Sanchez-Diaz, Manuel
A1 Salvador-Rodriguez, Luis
A1 Montero-Vilchez, Trinidad
A1 Martinez-Lopez, Antonio
A1 Arias-Santiago, Salvador
A1 Molina-Leyva, Alejandro
K1 hidradenitis suppurativa
K1 cardiovascular risk
K1 intima-media thickness
K1 Atherosclerotic cardiovascular-disease
K1 Vitamin-d
K1 Subclinical atherosclerosis
K1 Glycated hemoglobin
K1 Metabolic syndrome
K1 Marker
K1 Plaque
K1 Metaanalysis
AB Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 mu m. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/26319
UL https://hdl.handle.net/10668/26319
LA en
DS RISalud
RD Apr 8, 2025