RT Journal Article
T1 The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation.
A1 Grilo, Israel
A1 Pascasio, Juan Manuel
A1 Tirado, Juan Luis
A1 López-Pardo, Francisco-Jesús
A1 Ortega-Ruiz, Francisco
A1 Sousa, José Manuel
A1 Rodríguez-Puras, María José
A1 Ferrer, María Teresa
A1 Gómez-Bravo, Miguel Ángel
A1 Grilo Reina, Antonio
AB The macro-aggregated albumin lung perfusion scan (99mTc-MAA) is a diagnostic method for hepatopulmonary syndrome (HPS). To determine the sensitivity of 99mTc-MAA in diagnosing HPS, to establish the utility of 99mTc-MAA in determining the influence of HPS on hypoxemia in patients with concomitant pulmonary disease and to determine the correlation between 99mTc-MAA values and other respiratory parameters. Data from 115 cirrhotic patients who were eligible for liver transplantation (LT) were prospectively analyzed. A transthoracic contrast echocardiography and 99mTc-MAA were performed in 85 patients, and 74 patients were diagnosed with HPS. The overall sensitivity of 99mTc-MAA for the diagnosis of HPS was 18.9% (14/74) in all of the HPS cases and 66.7% (4/6) in the severe to very severe cases. In HPS patients who did not have lung disease, the degree of brain uptake of 99mTc-MAA was correlated with the alveolar-arterial oxygen gradient (A-a PO2) (r = 0.32, p  The 99mTc-MAA is a low sensitivity test for the diagnosis of HPS that can be useful in patients who have concomitant lung disease and in severe to very severe cases of HPS. It was not related to mortality, and brain uptake normalized after LT.
SN 1130-0108
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10967
UL http://hdl.handle.net/10668/10967
LA en
DS RISalud
RD Apr 7, 2025