RT Journal Article
T1 The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation.
A1 Grilo, Israel
A1 Pascasio, Juan Manuel
A1 Tirado, Juan Luis
A1 Lopez-Pardo, Francisco-Jesus
A1 Ortega-Ruiz, Francisco
A1 Sousa, Jose Manuel
A1 Rodriguez-Puras, Maria Jose
A1 Ferrer, Maria Teresa
A1 Gomez-Bravo, Miguel Angel
A1 Grilo Reina, Antonio
K1 Hepatopulmonary syndrome
K1 Lung perfusion scan
K1 Technetium Tc 99m macroaggregated albumin
K1 Hypoxemia
K1 Liver transplantation
K1 Pulmonary disease
AB The macro-aggregated albumin lung perfusion scan (99mTc-MAA) is a diagnostic method for hepatopulmonary syndrome (HPS). To determine the sensitivity of 99mTc-MAA in diagnosing HPS, to establish the utility of 99mTc-MAA in determining the influence of HPS on hypoxemia in patients with concomitant pulmonary disease and to determine the correlation between 99mTc-MAA values and other respiratory parameters. Data from 115 cirrhotic patients who were eligible for liver transplantation (LT) were prospectively analyzed. A transthoracic contrast echocardiography and 99mTc-MAA were performed in 85 patients, and 74 patients were diagnosed with HPS. The overall sensitivity of 99mTc-MAA for the diagnosis of HPS was 18.9% (14/74) in all of the HPS cases and 66.7% (4/6) in the severe to very severe cases. In HPS patients who did not have lung disease, the degree of brain uptake of 99mTc-MAA was correlated with the alveolar-arterial oxygen gradient (A-a PO2) (r = 0.32, p  The 99mTc-MAA is a low sensitivity test for the diagnosis of HPS that can be useful in patients who have concomitant lung disease and in severe to very severe cases of HPS. It was not related to mortality, and brain uptake normalized after LT.
PB Sociedad Espanola de Patologia Digestiva
SN 1130-0108
YR 2017
FD 2017-05
LK http://hdl.handle.net/10668/10967
UL http://hdl.handle.net/10668/10967
LA en
NO Grilo I, Pascasio JM, Tirado JL, López-Pardo FJ, Ortega-Ruiz F, Sousa JM, et al.  The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation. Rev Esp Enferm Dig. 2017 May;109(5):335-343.
DS RISalud
RD Aug 13, 2025