RT Journal Article
T1 Does experienced pain affects local brain volumes? Insights from a clinical acute pain model.
A1 Torrecillas-Martínez, Laura
A1 Catena, Andrés
A1 O'Valle, Francisco
A1 Padial-Molina, Miguel
A1 Galindo-Moreno, Pablo
K1 Acute pain
K1 Brain morphometry
K1 Cortical volume
K1 Experiment
K1 Subcortical nuclei shape
AB Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.
YR 2019
FD 2019-03-04
LK https://hdl.handle.net/10668/24745
UL https://hdl.handle.net/10668/24745
LA en
DS RISalud
RD Apr 8, 2025