RT Generic
T1 Dry care versus chlorhexidine cord care for prevention of omphalitis. Systematic review with meta-analysis
A1 Dolores Lopez-Medina, Maria
A1 Linares-Abad, Manuel
A1 Belen Lopez-Araque, Ana
A1 Maria Lopez-Medina, Isabel
K1 Umbilical Cord
K1 Chlorhexidine
K1 Skin Care
K1 Infection
K1 Meta-Analysis
K1 Infant, Newborn
K1 Umbilical-cord
K1 Neonatal-mortality
K1 Topical application
K1 Southern nepal
K1 Triple dye
K1 Separation
K1 Time
K1 Newborns
K1 District
K1 Alcohol
AB Objective: to compare the effect of dry care and the application of chlorhexidine to the umbilical cord of newborns at risk of developing omphalitis. Method: systematic review with meta-analysis. Clinical trials comparing dry care with the application of clorexidine to evaluate omphalitis were selected. Methodological quality was evaluated using the Consolidated Standards of Reporting Trials. Results: the joint analysis of the studies shows a significant decrease in the risk of omphalitis in the chlorhexidine group compared to the dry care group (RR=0.58, CI: 0.53-0.64). However, in the analysis by subgroups, chlorhexidine umbilical cord care did not reduce the risk of omphalitis in hospital births (RR=0.82, CI: 0.64-1.05), in countries with a low infant mortality rate (RR=0.8, CI: 0.5-1.28), or at chlorhexidine concentrations below 4% (RR=0.55, CI: 0.31-1). Chlorhexidine acted as a protective factor at a concentration of 4% (RR=0.58, CI: 0.53-0.64), when applied in cases of home births (RR=0.57, CI: 0.51-0.62), in countries with a high infant mortality rate (RR=0.57, CI: 0.52-0.63). Conclusion: dry cord care is effective in countries with low infant mortality rate and in hospital births. However, 4% chlorhexidine for umbilical cord care protects against omphalitis in home births, in countries with a high infant mortality rate.
PB Univ sao paulo, escola de enfermagem de ribeirao preto
SN 1518-8345
YR 2019
FD 2019-01-01
LK http://hdl.handle.net/10668/19193
UL http://hdl.handle.net/10668/19193
LA en
DS RISalud
RD Apr 8, 2025