RT Journal Article
T1 Relevant gender differences in epidemiological profile, exposure to first antiretroviral regimen and survival in the Spanish AIDS Research Network Cohort.
A1 Pérez-Elías, María Jesús
A1 Muriel, Alfonso
A1 Moreno, Ana
A1 Martínez-Colubi, María
A1 Iribarren, José A
A1 Masiá, Mar
A1 Blanco, José R
A1 Palacios, Rosario
A1 Romero, Jorge del
A1 Pérez, Desire G
A1 Hernando, Victoria
K1 Infecciones por VIH
K1 Factores sexuales
K1 Terapia antirretroviral altamente activa
K1 Fármacos anti-VIH
K1 Estudios de cohortes
K1 Factores de riesgo
K1 España
K1 Humanos
AB BACKGROUNDThe possible differences in the disease spectrum and prognosis of HIV infection in women and men is a major point of concern. Women are under-represented in randomized clinical trials and in some cohorts. Discordant results have often been obtained depending on the setting.METHODSWe assessed gender differences in clinical and epidemiological features, antiretroviral treatment (ART) exposure and survival in two multicentre cohorts of HIV-positive subjects in Spain: CoRIS-MD and CoRIS. Competing risk regression models were used to assess gender effect on time to start ART and time to first ART change, and a Cox regression model to estimate gender effect on time to death.RESULTSBetween January 1996 and December 2008, 1,953 women and 6,072 men naive to ART at study entry were included. The trend analysis over time showed the percentage of women in the younger (<20 years) and older (>50 years) strata increased significantly (P<0.001) from 0.5% and 1.8% in 1996 to 4.9% and 4.2% in 2008, respectively. By competing risk analysis women started ART earlier than men (adjusted subhazard ratio [ASHR] 1.21, 95% CI 1.11, 1.31) in CoRIS cohort, while in CoRIS-MD none of these differences were observed. In both cohorts women showed a shorter time to the first ART change (ASHR 1.10, 95% CI 1.01, 1.19). Pregnancy and patient's/physician's decisions as reasons for changing were more frequent in women than in men in CoRIS. In the Cox regression model, gender was not associated with differences in survival.CONCLUSIONSIn two large cohorts in Spain, we observed relevant gender differences in epidemiological characteristics and antiretroviral exposure outcomes, while survival differences were not attributable to gender.
PB International Medical Press
SN 1359-6535
YR 2014
FD 2014-09
LK http://hdl.handle.net/10668/1787
UL http://hdl.handle.net/10668/1787
LA en
NO Pérez-Elías MJ, Muriel A, Moreno A, Martínez-Colubi M, Iribarren JA, Masiá M, et al. Relevant gender differences in epidemiological profile, exposure to first antiretroviral regimen and survival in the Spanish AIDS Research Network Cohort. Antivir Ther. (Lond.). 2014; 19(4):375-85
NO Journal Article;
DS RISalud
RD Apr 12, 2025