RT Journal Article
T1 Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses).
A1 Hernáez, Álvaro
A1 Camps-Vilaró, Anna
A1 Polo-Alonso, Sara
A1 Subirana, Isaac
A1 Ramos, Rafel
A1 de Cid, Rafael
A1 Rodríguez-Artalejo, Fernando
A1 Elosua, Roberto
A1 Chirlaque, M Dolores
A1 Amiano, Pilar
A1 Bermúdez-López, Marcelino
A1 Guevara, Marcela
A1 Cinza-Sanjurjo, Sergio
A1 Sánchez, María José
A1 de León, Antonio Cabrera
A1 Laclaustra, Martín
A1 Rojo-Martínez, Gemma
A1 Guembe-Suescun, María J
A1 Pérez-Gómez, Beatriz
A1 Vega-Alonso, Tomás
A1 Torán-Monserrat, Pere
A1 Lora-Pablos, David
A1 Huerta, José María
A1 Valdivielso, José M
A1 Dégano, Irene R
A1 Félix-Redondo, Francisco J
A1 Gandarillas, Ana María
A1 Valdés, Sergio
A1 Mundet-Tuduri, Xavier
A1 Sánchez, Pedro L
A1 Martín-Sánchez, Vicente
A1 Rigo, Fernando
A1 Alonso-Sampedro, Manuela
A1 Moreno-Iribas, Conchi
A1 Martín-Escudero, Juan Carlos
A1 Delgado, Elías
A1 Grau, Maria
A1 Urrutia, Inés
A1 Ovejero, Diana
A1 Quintela, Inés
A1 Martí-Lluch, Ruth
A1 Blay, Natalia
A1 Banegas, José R
A1 Tizón-Marcos, Helena
A1 Gómez, Jesús Humberto
A1 Aizpurua, Amaia
A1 Castro-Boqué, Eva
A1 Delfrade, Josu
A1 Prieto-Díaz, Miguel Ángel
A1 Rodríguez-Barranco, Miguel
A1 Almeida-González, Delia
A1 Moreno-Franco, Belén
A1 Oualla-Bachiri, Wasima
A1 Sayón-Orea, Carmen
A1 Plans-Beriso, Elena
A1 Lozano, José Eugenio
A1 López-Lifante, Víctor M
A1 Cancelas-Navia, Pilar
A1 Cabrera-Castro, Natalia
A1 Cambray, Serafí
A1 Zacarías-Pons, Lluís
A1 Fernández-Bergés, Daniel
A1 Donoso-Navarro, Encarnación
A1 Maldonado-Araque, Cristina
A1 Franch-Nadal, Josep
A1 Dorado-Díaz, Pedro Ignacio
A1 Villarín-Castro, Alejandro
A1 Frontera-Juan, Guillem
A1 Gude, Francisco
A1 Andueza, Naroa
A1 Téllez-Plaza, María
A1 Ares-Blanco, Jessica
A1 Cruz, Raquel
A1 Ribas-Aulinas, Marc
A1 Barretina, Jordi
A1 Guallar-Castillón, Pilar
A1 Caínzos-Achirica, Miguel
A1 Colorado-Yohar, Sandra Milena
A1 Llorente, Adrián
A1 Diaz-Tocados, Juan Miguel
A1 Ardanaz, Eva
A1 Micó-Pérez, Rafael Manuel
A1 Fernández-Martínez, Nicolás Francisco
A1 Del Cristo Rodríguez-Pérez, María
A1 Cenarro, Ana
A1 Calle-Pascual, Alfonso L
A1 Marrugat, Jaume
K1 Cardiovascular disease
K1 Cohort
K1 Genome-wide association study
K1 Mortality
K1 Southern Europe
AB The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population, improve predictions of cardiovascular incidence using genomic and clinical data, and identify subgroups that would benefit most from targeted pharmacological and lifestyle interventions. CORDELIA includes 196,632 individuals (ages 18-84, 54% female, 96% born in Spain, 20% with higher education, recruited from 1989 to 2020, with follow-up periods ranging from 5 to 30 years), with DNA samples available for 117,342 participants (60%). Of the participants, 24% were current smokers, 43% hypertensive, 11% diabetic, 15% medicated with lipid-lowering drugs, 44% overweight, and 27% obese. If not already available, genotyping is being performed using the Axiom™ Spain Biobank array (~ 750,000 variants, including 115,000 specific and 50,000 rare functional variants from the Spanish population). The cohort also includes incident events (coronary heart disease, stroke, heart failure, peripheral artery disease, hypertension, diabetes); date and cause of death; and harmonized data on risk factors (body mass index, waist circumference, lipid profile, blood pressure, glucose, creatinine), lifestyle (smoking, physical activity, diet, alcohol), and socioeconomic status. 99,019 participants (50%) also provide plasma samples. CORDELIA will significantly contribute to understanding the complex interplay of risk factors contributing to cardiovascular disease and advance the fields of precision medicine and public health in Southern European individuals.
PB Kluwer Academic Publishers
YR 2025
FD 2025-05-12
LK https://hdl.handle.net/10668/28519
UL https://hdl.handle.net/10668/28519
LA en
NO Hernáez Á, Camps-Vilaró A, Polo-Alonso S, Subirana I, Ramos R, de Cid R, et al. Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses). Eur J Epidemiol. 2025 May 12.
NO The CORDELIA Study variable harmonization and GWAS were funded by Instituto de Salud Carlos III and co-funded by the European Union (Proyecto de Investigación de Medicina Personalizada de Precisión PMP22/00033, and projects PI21/00040 and PI21/00163). A detailed description of the funding sources of the individual cohorts is available in Appendix II.
DS RISalud
RD Sep 12, 2025