TY  - JOUR
AU  - Herrero-Ruiz, Andrés
AU  - Martínez-García, Pedro Manuel
AU  - Terrón-Bautista, José
AU  - Millán-Zambrano, Gonzalo
AU  - Lieberman, Jenna Ariel
AU  - Jimeno-González, Silvia
AU  - Cortés-Ledesma, Felipe
PY  - 2021
DO  - 10.1016/j.celrep.2021.108977
UR  - http://hdl.handle.net/10668/3655
T2  - Cell Reports
AB  - Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore...
LA  - en
PB  - Cell Press
KW  - DNA supercoiling
KW  - DNA topoisomerases
KW  - DNA topology
KW  - Gene expression
KW  - Promoter-proximal pausing
KW  - Transcription elongation
KW  - ADN-topoisomerasas
KW  - Expresión génica
KW  - Elongación de la transcripción genética
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::DNA Topoisomerases::DNA Topoisomerases, Type II
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Circular::DNA, Superhelical
KW  - Medical Subject Headings::Anatomy::Cells::Epithelial Cells
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Immediate-Early
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Protein Binding
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Proto-Oncogene Proteins c-fos
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Nucleotidyltransferases::RNA Nucleotidyltransferases::DNA-Directed RNA Polymerases::RNA Polymerase II
KW  - Medical Subject Headings::Anatomy::Sense Organs::Eye::Retina::Retinal Pigment Epithelium
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Barbiturates::Thiobarbiturates
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Topoisomerase Inhibitors::Topoisomerase II Inhibitors
TI  - Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
TY  - research article
ER  -