RT Journal Article
T1 Point-of-care haemostasis monitoring during liver transplantation is cost effective
A1 Leon-Justel, Antonio
A1 Alvarez-Rios Ana I, 
A1 Noval-Padillo, Miguel A
A1 Gómez-Bravo, Miguel Ángel
A1 Porras, Manuel
A1 Gomez-Sosa, Laura
A1 Lopez-Romero, Juan L
A1 Guerrero, Juan M
K1 Blood loss
K1 Cost effective
K1 Liver transplantation
K1 Mobile laboratory
K1 Point of care testing
K1 Costos y análisis de costo
K1 Laboratorios
K1 Pruebas en el punto de atención
K1 Trasplante de hígado
K1 Sangre
AB Background: Optimal haemostasis management in orthotropic liver transplant (OLT) could reduce blood loss and transfusion volume, improve patient outcomes and reduce cost.Methods: We performed a study including 336 OLTs to evaluate the clinical and cost effectiveness of a new pointof- care (POC)-based haemostatic management approach in OLT patients.Results: In terms of health benefit we found that the new approach showed a significant reduction in transfusion requirements (red blood cell transfusion units were reduced from 5.3 ± 4.6 to 2.8 ± 2.9 [p < 0.001], free frozen plasma from 3.1 ± 3.3 to 0.4 ± 1.0 [p < 0.001] and platelets from 2.9 ± 3.9 to 0.4 ± 0.9 [p < 0.001], transfusion avoidance, 9.7% vs. 29.1% [p < 0.001] and massive transfusion, 14.5% vs. 3.8% [p = 0.001]); we also found a significant improvement in patient outcomes, such, reoperation for bleeding or acute-kidney-failure (8.3% vs. 2.4%, p = 0.015; 33.6% vs. 5.4%, p < 0.001), with a significant reduction in the length of the hospital total stay (40.6 ± 13.8 days vs. 38.2 ± 14.4 days, p = 0.001). The lowest cost incurred was observed with the new approach (€73,038.80 vs. €158,912.90) with significant patient saving associated to transfusion avoidance (€1278.36), ICU-stay (€3037.26),total-stay (€3800.76) and reoperation for bleeding (€80,899.64).Conclusions: POC haemostatic monitoring during OLT is cost effective.
PB De Gruyter
SN 1437-4331
YR 2019
FD 2019
LK https://hdl.handle.net/10668/23211
UL https://hdl.handle.net/10668/23211
LA en
NO Leon-Justel A, Alvarez-Rios AI, Noval-Padillo JA, Gomez-Bravo MA, Porras M, Gomez-Sosa L, Lopez-Romero JL, Guerrero JM. Point-of-care haemostasis monitoring during liver transplantation is cost effective. Clin Chem Lab Med. 2019 May 27;57(6):883-890
DS RISalud
RD Apr 4, 2025