RT Journal Article
T1 Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimod.
A1 Piñar Morales, Raquel
A1 Carrasco Garcia, María
A1 Gutierrez-Rojas, Luis
A1 Barrero Hernández, Francisco Javier
K1 Fingolimod
K1 Immune reconstitution inflammatory syndrome
K1 Magnetic resonance imaging
K1 Multiple sclerosis
K1 Progressive multifocal leukoencephalopathy
AB Progressive multifocal leukoencephalopathy (PML) is a rare complication of immunosuppressive treatment in MS patients. Immune reconstitution inflammatory syndrome (IRIS) appears after the withdrawal of certain drugs such as natalizumab (NTZ) or fingolimod. The development of PML-IRIS after NTZ treatment has been described, and its diagnosis is made by clinical and radiological criteria and the determination of the John Cunningham virus in CSF. We present a clinical case of a patient with MS who, after the withdrawal of fingolimod, developed PML-IRIS despite sustained lymphopenia. This is important for pharmacovigilance purposes, not only for NTZ but also for alternative drugs used in MS treatment.
SN 1662-680X
YR 2022
FD 2022-02-07
LK http://hdl.handle.net/10668/20191
UL http://hdl.handle.net/10668/20191
LA en
DS RISalud
RD Apr 9, 2025