%0 Journal Article
%A Piñar Morales, Raquel
%A Carrasco Garcia, María
%A Gutierrez-Rojas, Luis
%A Barrero Hernández, Francisco Javier
%T Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimod.
%D 2022
%@ 1662-680X
%U http://hdl.handle.net/10668/20191
%X Progressive multifocal leukoencephalopathy (PML) is a rare complication of immunosuppressive treatment in MS patients. Immune reconstitution inflammatory syndrome (IRIS) appears after the withdrawal of certain drugs such as natalizumab (NTZ) or fingolimod. The development of PML-IRIS after NTZ treatment has been described, and its diagnosis is made by clinical and radiological criteria and the determination of the John Cunningham virus in CSF. We present a clinical case of a patient with MS who, after the withdrawal of fingolimod, developed PML-IRIS despite sustained lymphopenia. This is important for pharmacovigilance purposes, not only for NTZ but also for alternative drugs used in MS treatment.
%K Fingolimod
%K Immune reconstitution inflammatory syndrome
%K Magnetic resonance imaging
%K Multiple sclerosis
%K Progressive multifocal leukoencephalopathy
%~