RT Journal Article
T1 Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
A1 Gomez-Samblas, M
A1 Bernal, D
A1 Bolado-Ortiz, A
A1 Vilchez, S
A1 Bolás-Fernández, F
A1 Espino, A M
A1 Trelis, M
A1 Osuna, A
AB Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p 
YR 2018
FD 2018-05-17
LK http://hdl.handle.net/10668/12484
UL http://hdl.handle.net/10668/12484
LA en
DS RISalud
RD Apr 10, 2025