%0 Journal Article
%A Gomez-Samblas, M
%A Bernal, D
%A Bolado-Ortiz, A
%A Vilchez, S
%A Bolás-Fernández, F
%A Espino, A M
%A Trelis, M
%A Osuna, A
%T Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
%D 2018
%U http://hdl.handle.net/10668/12484
%X Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p 
%~