RT Journal Article T1 The Exposome and Immune Health in Times of the COVID-19 Pandemic. A1 Morales, Javier S A1 Valenzuela, Pedro L A1 Castillo-Garcia, Adrián A1 Butragueño, Javier A1 Jimenez-Pavon, David A1 Carrera-Bastos, Pedro A1 Lucia, Alejandro K1 COVID-19 K1 Environmental exposure K1 Healthy lifestyle K1 Infectious diseases K1 Vaccines AB Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics. PB MDPI YR 2021 FD 2021-12-19 LK http://hdl.handle.net/10668/21447 UL http://hdl.handle.net/10668/21447 LA en NO Morales JS, Valenzuela PL, Castillo-García A, Butragueño J, Jiménez-Pavón D, Carrera-Bastos P, et al. The Exposome and Immune Health in Times of the COVID-19 Pandemic. Nutrients. 2021 Dec 22;14(1):24 DS RISalud RD Apr 11, 2025