RT Journal Article
T1 Asymmetric cell division requires specific mechanisms for adjusting global transcription.
A1 Mena, Adriana
A1 Medina, Daniel A
A1 Garcia-Martinez, Jose
A1 Begley, Victoria
A1 Singh, Abhyudai
A1 Chavez, Sebastian
A1 Muñoz-Centeno, Mari C
A1 Perez-Ortin, Jose E
K1 Cell Cycle
K1 DNA-Directed RNA Polymerases
K1 RNA Stability
K1 Saccharomyces cerevisiae
K1 Transcription, Genetic
AB Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme.
PB Oxford University Press
YR 2017
FD 2017-10-23
LK http://hdl.handle.net/10668/11729
UL http://hdl.handle.net/10668/11729
LA en
NO Mena A, Medina DA, García-Martínez J, Begley V, Singh A, Chávez S, et al. Asymmetric cell division requires specific mechanisms for adjusting global transcription. Nucleic Acids Res. 2017 Dec 1;45(21):12401-12412.
DS RISalud
RD Apr 10, 2025