RT Journal Article
T1 Circulating Tumor Cells Identify Early Recurrence in Patients with Non-Small Cell Lung Cancer Undergoing Radical Resection.
A1 Bayarri-Lara, Clara
A1 Ortega, Francisco G
A1 Cueto Ladrón de Guevara, Antonio
A1 Puche, Jose L
A1 Ruiz Zafra, Javier
A1 de Miguel-Pérez, Diego
A1 Sánchez-Palencia Ramos, Abel
A1 Giraldo-Ospina, Carlos Fernando
A1 Navajas Gómez, Juan A
A1 Delgado-Rodriguez, Miguel
A1 Lorente, Jose A
A1 Serrano, María Jose
K1 Carcinoma de pulmón de células no pequeñas
K1 Supervivencia sin enfermedad
K1 Humanos
K1 Análisis multivariante
K1 Recurrencia local de neoplasia
K1 Pronóstico
K1 Estudios prospectivos
K1 Receptor del factor de crecimiento epidérmico
K1 Riesgo
AB BACKGROUNDSurgery is the treatment of choice for patients with non-small cell lung cancer (NSCLC) stages I-IIIA. However, more than 20% of these patients develop recurrence and die due to their disease. The release of tumor cells into peripheral blood (CTCs) is one of the main causes of recurrence of cancer. The objectives of this study are to identify the prognostic value of the presence and characterization of CTCs in peripheral blood in patients undergoing radical resection for NSCLC.PATIENTS AND METHODS56 patients who underwent radical surgery for previously untreated NSCLC were enrolled in this prospective study. Peripheral blood samples for CTC analysis were obtained before and one month after surgery. In addition CTCs were phenotypically characterized by epidermal growth factor receptor (EGFR) expression.RESULTS51.8% of the patients evaluated were positive with the presence of CTCs at baseline. A decrease in the detection rate of CTCs was observed in these patients one month after surgery (32.1%) (p = 0.035). The mean number of CTCs was 3.16 per 10 ml (range 0-84) preoperatively and 0.66 (range 0-3) in postoperative determination. EGFR expression was found in 89.7% of the patients at baseline and in 38.9% patients one month after surgery. The presence of CTCs after surgery was significantly associated with early recurrence (p = 0.018) and a shorter disease free survival (DFS) (p = .008). In multivariate analysis CTC presence after surgery (HR = 5.750, 95% CI: 1.50-21.946, p = 0.010) and N status (HR = 0.296, 95% CI: 0.091-0.961, p = 0.043) were independent prognostic factors for DFS.CONCLUSIONCTCs can be detected and characterized in patients undergoing radical resection for non-small cell lung cancer. Their presence might be used to identify patients with increased risk of early recurrence.
PB Public Library of Science
YR 2016
FD 2016-02-25
LK http://hdl.handle.net/10668/2234
UL http://hdl.handle.net/10668/2234
LA en
NO Bayarri-Lara C, Ortega FG, Cueto Ladrón de Guevara A, Puche JL, Ruiz Zafra J, de Miguel-Pérez D, et al. Circulating Tumor Cells Identify Early Recurrence in Patients with Non-Small Cell Lung Cancer Undergoing Radical Resection. PLoS ONE. 2016; 11(2):e0148659
NO Journal Article;
DS RISalud
RD Apr 5, 2025