RT Journal Article
T1 IL7RA rs6897932 Polymorphism is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy.
A1 Resino, Salvador
A1 Navarrete-Muñoz, María A
A1 Blanco, Julià
A1 Pacheco, Yolanda M
A1 Castro, Iván
A1 Berenguer, Juan
A1 Santos, Jesús
A1 Vera-Méndez, Francisco J
A1 Górgolas, Miguel
A1 Jiménez-Sousa, M A Ángeles
A1 Benito, José M
A1 Rallón, Norma
A1 CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015, 
K1 CD4
K1 HIV
K1 IL7RA
K1 SNPs
K1 cART
K1 immune reconstitution
AB Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism is related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count 20% and was in Hardy-Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini-Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count
YR 2019
FD 2019-06-16
LK http://hdl.handle.net/10668/14132
UL http://hdl.handle.net/10668/14132
LA en
DS RISalud
RD Apr 6, 2025