RT Journal Article
T1 Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity.
A1 Martinez-García, Miguel Ángel
A1 Olveira, Casilda
A1 Girón, Rosa
A1 García-Clemente, Marta
A1 Máiz-Carro, Luis
A1 Sibila, Oriol
A1 Golpe, Rafael
A1 Méndez, Raúl
A1 Rodríguez Hermosa, Juan Luis
A1 Barreiro, Esther
A1 Prados, Concepción
A1 Rodríguez López, Juan
A1 de la Rosa, David
K1 bronchiectasis
K1 exacerbations
K1 lymphocyte
K1 neutrophil
K1 severity
AB Most patients with bronchiectasis have a predominantly neutrophilic inflammatory profile, although other cells such as lymphocytes (as controllers of bronchial inflammation) and eosinophils also play a significant pathophysiological role. Easy-to-interpret blood biomarkers with a discriminative capacity for severity or prognosis are needed. The objective of this study was to assess whether the peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with different outcomes of severity in bronchiectasis. A total of 1369 patients with bronchiectasis from the Spanish Registry of Bronchiectasis were included. To compare groups, the sample was divided into increasing quartiles of NLR ratio. Correlations between quantitative variables were established using Pearson's P test. A simple linear regression (with the value of exacerbations as a quantitative variable) was used to determine the independent relationship between the number and severity of exacerbations and the NLR ratio. The area under the curve (AUC)-ROC was used to determine the predictive capacity of the NLR for severe bronchiectasis, according to the different multidimensional scores. Mean age: 69 (15) years (66.3% of women). The mean NLR was 2.92 (2.03). A higher NLR was associated with more severe bronchiectasis (with an especially significant discriminative power for severe forms) according to the commonly used scores (FACED, E-FACED and BSI), as well as with poorer quality of life (SGRQ), more comorbidities (Charlson index), infection by pathogenic microorganisms, and greater application of treatment. Furthermore, the NLR correlated better with severity scores than other parameters of systemic inflammation. Finally, it was an independent predictor of the incident number and severity of exacerbations. In conclusion, the NLR is an inexpensive and easy-to-measure marker of systemic inflammation for determining severity and predicting exacerbations (especially the most severe) in patients with bronchiectasis.
YR 2022
FD 2022-09-30
LK http://hdl.handle.net/10668/20810
UL http://hdl.handle.net/10668/20810
LA en
DS RISalud
RD Apr 11, 2025