TY  - JOUR
AU  - Ruz-Maldonado, Inmaculada
AU  - Pingitore, Attilio
AU  - Liu, Bo
AU  - Atanes, Patricio
AU  - Huang, Guo Cai
AU  - Baker, David
AU  - Alonso, Francisco José
AU  - Bermúdez-Silva, Francisco Javier
AU  - Persaud, Shanta J
PY  - 2018
DO  - 10.1111/dom.13180
UR  - http://hdl.handle.net/10668/11877
T2  - Diabetes, obesity & metabolism
AB  - To examine the effects of Abn-CBD (GPR55 agonist) and LH-21 (CB1 antagonist) on human and mouse islet function, and to determine signalling via GPR55 using islets from GPR55-/- mice. Islets isolated from human organ donors and mice were incubated in...
LA  - en
KW  - cannabinoids
KW  - insulin secretion
KW  - islets
KW  - proliferation
KW  - β-cell function
KW  - Adult
KW  - Animals
KW  - Cells, Cultured
KW  - Female
KW  - Humans
KW  - Insulin-Secreting Cells
KW  - Islets of Langerhans
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Middle Aged
KW  - Receptors, Cannabinoid
KW  - Receptors, G-Protein-Coupled
KW  - Resorcinols
KW  - Signal Transduction
KW  - Triazoles
TI  - LH-21 and abnormal cannabidiol improve β-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling.
TY  - research article
VL  - 20
ER  -