RT Journal Article
T1 Advances in spray products for skin regeneration.
A1 Pleguezuelos-Beltran, Paula
A1 Galvez-Martin, Patricia
A1 Nieto-Garcia, Daniel
A1 Marchal, Juan Antonio
A1 Lopez-Ruiz, Elena
K1 ATMP, advanced therapy medicinal product
K1 BLA, Biologic License Application
K1 CAT, Committee for Advances Therapies
K1 CEA, cultured epithelial autograft
K1 CFR, Code of Federal Regulations
K1 CHMP, Committee for Medicinal Product for Human Use
K1 CTD, Common Technical Document
K1 DMEM, Dulbecco's Modified Eagle's medium
K1 ECM, extracellular matrix
K1 EMA, European Medicines Agency
K1 EU, European Union
K1 FDA, Food and Drug Administration
K1 Fibrin
K1 GAGs, glycosaminoglycans
K1 GLP, Good Laboratory Practice
K1 GMP, Good Manufacturing Practice
K1 HA, hyaluronic acid
K1 HCT/Ps, human cells, tissues, and cellular and tissue-based products
K1 Hydrogel
K1 ISO, International Organization for Standardization
K1 MA, marketing authorization
K1 NP, Notified body
K1 OTAT, Office of Tissues and Advanced Therapies
K1 PCL, polycaprolactone
K1 PEG, polyethylene glycol
K1 PHSA, Public Health Service Act
K1 PMA, Premarket Approval
K1 PRF, platelet rich fibrin
K1 PRP, platelet rich plasma
K1 PU, polyurethane
K1 QMS, Quality Management System
K1 Skin
K1 Spray
K1 TE, tissue engineering
K1 Tissue engineering
K1 USA, United States of America
AB To date, skin wounds are still an issue for healthcare professionals. Although numerous approaches have been developed over the years for skin regeneration, recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes, including 3D bioprinting, electrospinning or spraying, among others. In particular, skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic wounds. Skin sprays present significant advantages compared to conventional treatments for wound healing, such as the facility of application, the possibility to treat large wound areas, or the homogeneous distribution of the sprayed material. In this article, we review the latest advances in this technology, giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products, used for a variety of diseases and applying different experimental materials. Moreover, as skin sprays products are subjected to different classifications, we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment conditions. Finally, we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.
PB KeAi Publishing Communications Ltd
YR 2022
FD 2022-02-18
LK http://hdl.handle.net/10668/22032
UL http://hdl.handle.net/10668/22032
LA en
NO Pleguezuelos-Beltrán P, Gálvez-Martín P, Nieto-García D, Marchal JA, López-Ruiz E. Advances in spray products for skin regeneration. Bioact Mater. 2022 Mar 8;16:187-203.
DS RISalud
RD Apr 6, 2025