TY  - JOUR
AU  - Sanchez-Luque, Francisco J
AU  - Kempen, Marie-Jeanne H C
AU  - Gerdes, Patricia
AU  - Vargas-Landin, Dulce B
AU  - Richardson, Sandra R
AU  - Troskie, Robin-Lee
AU  - Jesuadian, J Samuel
AU  - Cheetham, Seth W
AU  - Carreira, Patricia E
AU  - Salvador-Palomeque, Carmen
AU  - García-Cañadas, Marta
AU  - Muñoz-Lopez, Martin
AU  - Sanchez, Laura
AU  - Lundberg, Mischa
AU  - Macia, Angela
AU  - Heras, Sara R
AU  - Brennan, Paul M
AU  - Lister, Ryan
AU  - Garcia-Perez, Jose L
AU  - Ewing, Adam D
AU  - Faulkner, Geoffrey J
PY  - 2019
DO  - 10.1016/j.molcel.2019.05.024
UR  - http://hdl.handle.net/10668/14159
T2  - Molecular cell
AB  - Epigenetic silencing defends against LINE-1 (L1) retrotransposition in mammalian cells. However, the mechanisms that repress young L1 families and how L1 escapes to cause somatic genome mosaicism in the brain remain unclear. Here we report that a...
LA  - en
KW  - DNA methylation
KW  - L1
KW  - LINE-1
KW  - YY1
KW  - epigenetics
KW  - neuroscience
KW  - retrotransposon
KW  - single-cell genomics
KW  - Binding Sites
KW  - DNA Methylation
KW  - DNA-Binding Proteins
KW  - Epigenetic Repression
KW  - Genome, Human
KW  - Hippocampus
KW  - Humans
KW  - Liver
KW  - Long Interspersed Nucleotide Elements
KW  - Neurons
KW  - Retroelements
KW  - Single-Cell Analysis
KW  - YY1 Transcription Factor
TI  - LINE-1 Evasion of Epigenetic Repression in Humans.
TY  - research article
VL  - 75
ER  -