RT Journal Article
T1 Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.
A1 Podmore, Clara
A1 Meidtner, Karina
A1 Schulze, Matthias B
A1 Scott, Robert A
A1 Ramond, Anna
A1 Butterworth, Adam S
A1 Di Angelantonio, Emanuele
A1 Danesh, John
A1 Arriola, Larraitz
A1 Barricarte, Aurelio
A1 Boeing, Heiner
A1 Clavel-Chapelon, Françoise
A1 Cross, Amanda J
A1 Dahm, Christina C
A1 Fagherazzi, Guy
A1 Franks, Paul W
A1 Gavrila, Diana
A1 Grioni, Sara
A1 Gunter, Marc J
A1 Gusto, Gaelle
A1 Jakszyn, Paula
A1 Katzke, Verena
A1 Key, Timothy J
A1 Kühn, Tilman
A1 Mattiello, Amalia
A1 Nilsson, Peter M
A1 Olsen, Anja
A1 Overvad, Kim
A1 Palli, Domenico
A1 Quirós, J Ramón
A1 Rolandsson, Olov
A1 Sacerdote, Carlotta
A1 Sánchez-Cantalejo, Emilio
A1 Slimani, Nadia
A1 Sluijs, Ivonne
A1 Spijkerman, Annemieke M W
A1 Tjonneland, Anne
A1 Tumino, Rosario
A1 van der A, Daphne L
A1 van der Schouw, Yvonne T
A1 Feskens, Edith J M
A1 Forouhi, Nita G
A1 Sharp, Stephen J
A1 Riboli, Elio
A1 Langenberg, Claudia
A1 Wareham, Nicholas J
AB Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D. The European Prospective Investigation into Cancer and Nutrition-InterAct study includes 12,403 incident T2D cases and a representative subcohort of 16,154 individuals from a European cohort with 3.99 million person-years of follow-up. We studied the prospective association of ferritin, TSAT, serum iron, and transferrin with incident T2D in 11,052 cases and a random subcohort of 15,182 individuals and assessed whether these associations differed by subgroups of the population. Higher levels of ferritin and transferrin were associated with a higher risk of T2D (hazard ratio [HR] [95% CI] in men and women, respectively: 1.07 [1.01-1.12] and 1.12 [1.05-1.19] per 100 μg/L higher ferritin level; 1.11 [1.00-1.24] and 1.22 [1.12-1.33] per 0.5 g/L higher transferrin level) after adjustment for age, center, BMI, physical activity, smoking status, education, hs-CRP, alanine aminotransferase, and γ-glutamyl transferase. Elevated TSAT (≥45% vs.  The pattern of association of TSAT and transferrin with T2D suggests that the underlying relationship between iron stores and T2D is more complex than the simple link suggested by the association of ferritin with T2D.
YR 2016
FD 2016-02-09
LK http://hdl.handle.net/10668/9821
UL http://hdl.handle.net/10668/9821
LA en
DS RISalud
RD Apr 18, 2025