RT Journal Article
T1 Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk.
A1 Marhuenda-Muñoz, Maria
A1 Dominguez-Lopez, Ines
A1 Langohr, Klaus
A1 Tresserra-Rimbau, Anna
A1 Martinez Gonzalez, Miguel Angel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Zomeño, Maria Dolores
A1 Martinez, J Alfredo
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Serra-Majem, Ll
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Martin-Sanchez, Vicente
A1 Pinto, Xavier
A1 Delgado-Rodriguez, Miguel
A1 Matia-Martin, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Ros, Emilio
A1 Toledo, Estefanía
A1 Fernandez de la Puente Cervera, Maria
A1 Barragan, Rocio
A1 Fito, Montse
A1 Tojal-Sierra, Lucas
A1 Gomez-Gracia, Enrique
A1 Zazo, Juan Manuel
A1 Morey, Marga
A1 Garcia-Rios, Antonio
A1 Casas, Rosa
A1 Gomez-Perez, Ana M
A1 Santos-Lozano, Jose Manuel
A1 Vazquez-Ruiz, Zenaida
A1 Atzeni, Alessandro
A1 Asensio, Eva M
A1 Gili-Riu, M Mar
A1 Bullon, Vanessa
A1 Moreno-Rodriguez, Anai
A1 Lecea, Oscar
A1 Babio, Nancy
A1 Peñas Lopez, Francesca
A1 Gomez Melis, Guadalupe
A1 Lamuela-Raventos, Rosa M
K1 Mediterranean diet
K1 PREDIMED-plus study
K1 Cardiovascular health
K1 Liquid chromatography
K1 Mass spectrometry
K1 Plasma carotenoids
AB Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 andd <0.00001 in women and men, respectively], lower levelsof plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 %(95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men,respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12% (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065and 0.0001 in women and men, respectively] in the whole population. Plasmacarotenoid concentrations were also associated with higher plasma HDLcholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001]
PB Frontiers Research Foundation
SN 2296-861X
YR 2022
FD 2022-09-05
LK http://hdl.handle.net/10668/20672
UL http://hdl.handle.net/10668/20672
LA en
NO Marhuenda-Muñoz M, Domínguez-López I, Langohr K, Tresserra-Rimbau A, Martínez González MÁ, Salas-Salvadó J, et al. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk. Front Nutr. 2022 Sep 29;9:967967
DS RISalud
RD Apr 7, 2025