RT Journal Article
T1 Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study.
A1 Naudin, Sabine
A1 Li, Kuanrong
A1 Jaouen, Tristan
A1 Assi, Nada
A1 Kyrø, Cecilie
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Rebours, Vinciane
A1 Védié, Anne-Laure
A1 Boeing, Heiner
A1 Kaaks, Rudolf
A1 Katzke, Verena
A1 Bamia, Christina
A1 Naska, Androniki
A1 Trichopoulou, Antonia
A1 Berrino, Franco
A1 Tagliabue, Giovanna
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Peeters, Petra H
A1 Bueno-de-Mesquita, H B As
A1 Weiderpass, Elisabete
A1 Gram, Inger Torhild
A1 Skeie, Guri
A1 Chirlaque, Maria-Dolores
A1 Rodriguez-Barranco, Miguel
A1 Barricarte, Aurelio
A1 Quiros, Jose Ramon
A1 Dorronsoro, Miren
A1 Johansson, Ingegerd
A1 Sund, Malin
A1 Sternby, Hanna
A1 Bradbury, Kathryn E
A1 Wareham, Nick
A1 Riboli, Elio
A1 Gunter, Marc
A1 Brennan, Paul
A1 Duell, Eric J
A1 Ferrari, Pietro
K1 Pancreatic Neoplasms
K1 Risk Factors
K1 Adult
K1 Alcoholism
K1 Dose-Response Relationship, Drug
K1 Humans
AB Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.
PB John Wiley & Sons, Inc.
YR 2018
FD 2018-03-09
LK http://hdl.handle.net/10668/12225
UL http://hdl.handle.net/10668/12225
LA en
NO Naudin S, Li K, Jaouen T, Assi N, Kyrø C, Tjønneland A, et al. Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer. 2018 Aug 15;143(4):801-812.
DS RISalud
RD Apr 11, 2025