RT Journal Article
T1 Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study.
A1 Castello, Adela
A1 Boldo, Elena
A1 Amiano, Pilar
A1 Castaño-Vinyals, Gemma
A1 Aragones, Nuria
A1 Gomez-Acebo, Ines
A1 Peiro, Rosana
A1 Jimenez-Moleon, Jose Juan
A1 Alguacil, Juan
A1 Tardon, Adonina
A1 Cecchini, Lluis
A1 Lope, Virginia
A1 Dierssen-Sotos, Trinidad
A1 Mengual, Lourdes
A1 Kogevinas, Manolis
A1 Pollan, Marina
A1 Perez-Gomez, Beatriz
K1 Mediterranean
K1 diet
K1 prevention & control
K1 principal component analysis
K1 prostatic neoplasms
K1 risk
AB We explored the association of the previously described Western, prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. MCC-Spain (Multicase-Control Study on Common Tumors in Spain) is a population based, multicase-control study that was done in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiological and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1,277 controls 38 to 85 years old. Three previously identified dietary patterns, including Western, prudent and Mediterranean, were reconstructed using MCC-Spain data. The association of each pattern with prostate cancer risk was assessed by logistic regression models with random, province specific intercepts. Risk according to tumor aggressiveness (Gleason score 6 vs greater than 6) and extension (cT1-cT2a vs cT2b-cT4) was evaluated by multinomial regression models. High adherence to a Mediterranean dietary pattern rich not only in fruits and vegetables but also in fish, legumes and olive oil was specifically associated with a lower risk of Gleason score greater than 6 prostate cancer (quartile 3 vs 1 relative RR 0.66, 95% CI 0.46-0.96 and quartile 4 vs 1 relative RR 0.68, 95% CI 0.46-1.01, p-trend = 0.023) or with higher clinical stage (cT2b-T4 quartile 4 vs 1 relative RR 0.49, 95% CI 0.25-0.96, p-trend = 0.024). This association was not observed with the prudent pattern, which combines vegetables and fruits with low fat dairy products, whole grains and juices. The Western pattern did not show any association with prostate cancer risk. Nutritional recommendations for prostate cancer prevention should consider whole dietary patterns instead of individual foods. We found important differences between the Mediterranean dietary pattern, which was associated with a lower risk of aggressive prostate cancer, and Western and prudent dietary patterns, which had no relationship with prostate cancer risk.
PB American Urological Association, Inc.
YR 2017
FD 2017-08-24
LK http://hdl.handle.net/10668/11531
UL http://hdl.handle.net/10668/11531
LA en
NO Castelló A, Boldo E, Amiano P, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, et al. MCC-Spain Researchers. Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study. J Urol. 2018 Feb;199(2):430-437
DS RISalud
RD Apr 7, 2025