RT Journal Article
T1 Diagnostic and prognostic assessment of suspected drug-induced liver injury in clinical practice.
A1 Andrade, Raúl J
A1 Robles-Díaz, Mercedes
K1 biomarkers
K1 chronic DILI
K1 diagnostic tools
K1 drug-induced liver injury
K1 phenotype
K1 prognostic models
AB Idiosyncratic drug-induced liver injury (DILI) is a challenging liver disorder because it can present with a range of phenotypes, mimicking almost every other hepatic disease, and lacks specific biomarkers for its diagnosis. Hence, a confident DILI diagnosis is seldom possible as it relies on the precise establishment of a temporal sequence between the exposure to a given prescription drug or sometimes hidden herbal product/over the counter medication as well as the exclusion of other aetiologies of liver disease. However, an accurate diagnosis is of most importance, as prompt withdrawal of the causative agent is essential in DILI management. Indeed, DILI can be severe and even fatal or in a fraction of cases evolve to chronic damage, but specific biomarkers for predicting mortality/liver transplantation or a chronic outcome in the very early phases of DILI are not yet available. In this article, we discuss the best diagnostic and prognostic approach of a DILI suspicion by judiciously choosing and interpreting the standard tests currently used in clinical practice.
YR 2019
FD 2019-10-14
LK http://hdl.handle.net/10668/14577
UL http://hdl.handle.net/10668/14577
LA en
DS RISalud
RD Aug 6, 2025