TY - JOUR AU - Gonzalez-Garcia, Pilar AU - Diaz-Casado, Maria Elena AU - Hidalgo-Gutierrez, Agustin AU - Jimenez-Sanchez, Laura AU - Bakkali, Mohammed AU - Barriocanal-Casado, Eliana AU - Escames, Germaine AU - Chiozzi, Riccardo Zenezini AU - Völlmy, Franziska AU - Zaal, Esther A AU - Berkers, Celia R AU - Heck, Albert J R AU - Lopez, Luis C PY - 2022 DO - 10.1016/j.redox.2022.102403 UR - http://hdl.handle.net/10668/22496 T2 - Redox biology AB - Defects in Coenzyme Q (CoQ) metabolism have been associated with primary mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The consequences of CoQ deficiency have not been fully addressed, and effective treatment remains... LA - en PB - Elsevier BV KW - Coenzyme Q KW - Mitochondrial disease KW - Omics KW - Phenolic compound KW - Therapy KW - Mice KW - Animals KW - Coenzyme Q10 Deficiency KW - Ubiquinone KW - Vanillic Acid KW - Proteome KW - Neuroinflammatory Diseases KW - Neurodegenerative Diseases KW - Gliosis KW - Mitochondrial Diseases KW - Metabolic Diseases KW - Brain KW - Phenotype KW - Kidney KW - Biomarkers TI - The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency. TY - research article VL - 55 ER -