RT Journal Article T1 Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial. A1 Cano-Ibañez, Naomi A1 Serra-Majem, Lluis A1 Martin-Pelaez, Sandra A1 Martinez-Gonzalez, Miguel Angel A1 Salas-Salvado, Jordi A1 Corella, Dolores A1 Lassale, Camille A1 Martinez, Jose Alfredo A1 Alonso-Gomez, Angel M A1 Wärnberg, Julia A1 Vioque, Jesus A1 Romaguera, Dora A1 Lopez-Miranda, Jose A1 Estruch, Ramon A1 Gomez-Perez, Ana Maria A1 Lapetra, Jose A1 Fernandez-Aranda, Fernando A1 Bueno-Cavanillas, Aurora A1 Tur, Josep A A1 Cubelos, Naiara A1 Pinto, Xavier A1 Gaforio, Jose Juan A1 Matia-Martin, Pilar A1 Vidal, Josep A1 Calderon, Cristina A1 Daimiel, Lidia A1 Ros, Emilio A1 Gea, Alfredo A1 Babio, Nancy A1 Gimenez-Alba, Ignacio Manuel A1 Zomeño-Fajardo, Maria Dolores A1 Abete, Itziar A1 Tojal Sierra, Lucas A1 Romero-Galisteo, Rita P A1 Garcia de la Hera, Manoli A1 Martin-Padillo, Marian A1 Garcia-Rios, Antonio A1 Casas, Rosa M A1 Fernandez-Garcia, J C A1 Santos-Lozano, Jose Manuel A1 Toledo, Estefania A1 Becerra-Tomas, Nerea A1 Sorli, Jose V A1 Schröder, Helmut A1 Zulet, María A A1 Sorto-Sanchez, Carolina A1 Diez-Espino, Javier A1 Gomez-Martinez, Carlos A1 Fito, Montse A1 Sanchez-Villegas, Almudena K1 Depression K1 Dietary diversity score K1 PREDIMED-Plus study AB To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms. An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used. Spanish older adults with metabolic syndrome (MetS). A total of 6625 adults aged 55-75 years from the PREDIMED-Plus study with overweight or obesity and MetS. Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v. Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3 v. C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v. C1 = (β = 0·70, 95 % CI (0·05, 1·35)). According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings. PB Cambridge University Press YR 2022 FD 2022-06-27 LK http://hdl.handle.net/10668/22582 UL http://hdl.handle.net/10668/22582 LA en NO Cano-Ibáñez N, Serra-Majem L, Martín-Peláez S, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial. Public Health Nutr. 2022 Jul 19;26(3):1-13 NO To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms. An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used. Spanish older adults with metabolic syndrome (MetS). A total of 6625 adults aged 55-75 years from the PREDIMED-Plus study with overweight or obesity and MetS. Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v. Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3 v. C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v. C1 = (β = 0·70, 95 % CI (0·05, 1·35)). According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings. 01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, The Especial Action Project entitled: ‘Implementaci ´on y Evaluaci ´on de una intervenci ´on intensiva sobre la actividad físicaCohorte PREDIMED-Plus’ grant to Jordi Salas-Salvad ´o, the Recercaixa grant to Jordi Salas-Salvad ´o (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant, and CIBEROBN and FEDER funds (CB06/03), ISCIII.International Nut&Dried Fruit Council- FESNAD Nº201302: Miguel Ángel Martínez-González (PI). None of the funding sources took part in the design, collection, analysis or interpretation of the data, or in the decision tosubmit the manuscript for publication. DS RISalud RD Apr 6, 2025