RT Journal Article
T1 Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity.
A1 Wang, Xuejie
A1 Villa, Carmen
A1 Dobarganes, Yadira
A1 Olveira, Casilda
A1 Girón, Rosa
A1 García-Clemente, Marta
A1 Máiz, Luis
A1 Sibila, Oriol
A1 Golpe, Rafael
A1 Menéndez, Rosario
A1 Rodríguez-López, Juan
A1 Prados, Concepción
A1 Martinez-García, Miguel Angel
A1 Rodriguez, Juan Luis
A1 de la Rosa, David
A1 Duran, Xavier
A1 Garcia-Ojalvo, Jordi
A1 Barreiro, Esther
K1 biostatistical analyses
K1 clinical outcomes
K1 disease severity scores
K1 eosinophil counts
K1 multivariate analyses
K1 non-cystic fibrosis bronchiectasis
K1 phenotypic clusters
AB Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann-Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications.
YR 2021
FD 2021-08-10
LK http://hdl.handle.net/10668/18446
UL http://hdl.handle.net/10668/18446
LA en
DS RISalud
RD Apr 20, 2025