RT Journal Article
T1 Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study.
A1 Benavente, Yolanda
A1 Costas, Laura
A1 Rodríguez-Suarez, Marta Maria
A1 Alguacil, Juan
A1 Santibañez, Miguel
A1 Vila, Javier
A1 Robles, Claudia
A1 Alonso, Esther
A1 de la Banda, Esmeralda
A1 Gonzalez-Barca, Eva
A1 Dierssen-Sotos, Trinidad
A1 Gimeno Vazquez, Eva
A1 Aymerich, Marta
A1 Campo, Elias
A1 Jimenez-Moleon, Jose J
A1 Marcos-Gragera, Rafael
A1 Castaño-Vinyals, Gemma
A1 Aragones, Nuria
A1 Pollan, Marina
A1 de Sanjose, Silvia
A1 Kogevinas, Manolis
A1 Tardon, Adonina
A1 Casabonne, Delphine
K1 chronic lymphocytic leukemia
K1 job-exposure matrix
K1 occupational exposure
K1 pesticides
AB We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010-2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.
PB MDPI AG
YR 2020
FD 2020-07-05
LK http://hdl.handle.net/10668/15995
UL http://hdl.handle.net/10668/15995
LA en
NO Benavente Y, Costas L, Rodríguez-Suarez MM, Alguacil J, Santibáñez M, Vila J, et al. Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study. Int J Environ Res Public Health. 2020 Jul 17;17(14):5174.
DS RISalud
RD Apr 9, 2025