RT Journal Article
T1 Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis
A1 López-Moreno, Ana
A1 Aguilera, Margarita
K1 Vaginal probiotics
K1 Reproductive dysbiosis
K1 Bacterial vaginosis
K1 VVC
K1 IVF
K1 Probióticos
K1 Vagina
K1 Disbiosis
K1 Salud reproductiva
K1 Vaginitis bacteriana
K1 Candidiasis vulvovaginal
K1 Fecundación in vitro
AB The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health-vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota-could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. The aim of the present review was to retrieve the standardized protocols of vaginal probiotics commonly used for investigating their microbiota modulation capacities. Most of the studies selected focused on treating bacterial vaginosis (BV) as the most common dysbiosis; a few studies focused on vulvovaginal candidiasis (VVC) and on pretreatment during in vitro fertilization (IVF). Vaginal probiotic doses administered were similar to oral probiotics protocols, ranging from ≥107 CFU/day to 2.5 × 1010 CFU/day, but were highly variable regarding the treatment duration timing. Moderate vaginal microbiota modulation was achieved; the relative abundance of abnormal microbiota decreased and Lactobacillus species increased.
PB MDPI
YR 2021
FD 2021-04-02
LK http://hdl.handle.net/10668/4155
UL http://hdl.handle.net/10668/4155
LA en
NO López-Moreno A, Aguilera M. Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis. J Clin Med. 2021 Apr 2;10(7):1461
DS RISalud
RD Apr 20, 2025