RT Journal Article
T1 Extracellular Vesicle-Based Therapeutics for Heart Repair.
A1 Saludas, Laura
A1 Oliveira, Cláudia C
A1 Roncal, Carmen
A1 Ruiz-Villalba, Adrián
A1 Prósper, Felipe
A1 Garbayo, Elisa
A1 Blanco-Prieto, María J
K1 cardiac repair
K1 cardiovascular diseases
K1 cargo loading
K1 drug delivery
K1 exosomes
K1 extracellular vesicles
K1 myocardial infarction
K1 targeting
AB Extracellular vesicles (EVs) are constituted by a group of heterogeneous membrane vesicles secreted by most cell types that play a crucial role in cell-cell communication. In recent years, EVs have been postulated as a relevant novel therapeutic option for cardiovascular diseases, including myocardial infarction (MI), partially outperforming cell therapy. EVs may present several desirable features, such as no tumorigenicity, low immunogenic potential, high stability, and fine cardiac reparative efficacy. Furthermore, the natural origin of EVs makes them exceptional vehicles for drug delivery. EVs may overcome many of the limitations associated with current drug delivery systems (DDS), as they can travel long distances in body fluids, cross biological barriers, and deliver their cargo to recipient cells, among others. Here, we provide an overview of the most recent discoveries regarding the therapeutic potential of EVs for addressing cardiac damage after MI. In addition, we review the use of bioengineered EVs for targeted cardiac delivery and present some recent advances for exploiting EVs as DDS. Finally, we also discuss some of the most crucial aspects that should be addressed before a widespread translation to the clinical arena.
SN 2079-4991
YR 2021
FD 2021-02-25
LK https://hdl.handle.net/10668/24758
UL https://hdl.handle.net/10668/24758
LA en
DS RISalud
RD Apr 10, 2025