RT Journal Article
T1 Obesity and Bone Health: A Complex Relationship.
A1 Piñar-Gutierrez, Ana
A1 Garcia-Fontana, Cristina
A1 Garcia-Fontana, Beatriz
A1 Muñoz-Torres, Manuel
K1 body composition
K1 fracture
K1 healthy aging
K1 inflammation
K1 obesity
K1 osteoporosis
AB Recent scientific evidence has shown an increased risk of fractures in patients with obesity, especially in those with a higher visceral adipose tissue content. This contradicts the old paradigm that obese patients were more protected than those with normal weight. Specifically, in older subjects in whom there is a redistribution of fat from subcutaneous adipose tissue to visceral adipose tissue and an infiltration of other tissues such as muscle with the consequent sarcopenia, obesity can accentuate the changes characteristic of this age group that predisposes to a greater risk of falls and fractures. Other factors that determine a greater risk in older subjects with obesity are chronic proinflammatory status, altered adipokine secretion, vitamin D deficiency, insulin resistance and reduced mobility. On the other hand, diagnostic tests may be influenced by obesity and its comorbidities as well as by body composition, and risk scales may underestimate the risk of fractures in these patients. Weight loss with physical activity programs and cessation of high-fat diets may reduce the risk. Finally, more research is needed on the efficacy of anti-osteoporotic treatments in obese patients.
PB MDPI AG
YR 2022
FD 2022-07-25
LK http://hdl.handle.net/10668/21180
UL http://hdl.handle.net/10668/21180
LA en
NO Piñar-Gutierrez A, García-Fontana C, García-Fontana B, Muñoz-Torres M. Obesity and Bone Health: A Complex Relationship. Int J Mol Sci. 2022 Jul 27;23(15):8303.
DS RISalud
RD Apr 12, 2025