RT Journal Article T1 Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A1 Navarrete-Muñoz, Eva M A1 Wark, Petra A A1 Romaguera, Dora A1 Bhoo-Pathy, Nirmala A1 Michaud, Dominique A1 Molina-Montes, Esther A1 Tjønneland, Anne A1 Olsen, Anja A1 Overvad, Kim A1 Boutron-Ruault, Marie-Christine A1 Clavel-Chapelon, Françoise A1 Fagherazzi, Guy A1 Katzke, Verena A A1 Kühn, Tilman A1 Steffen, Annika A1 Trichopoulou, Antonia A1 Klinaki, Eleni A1 Papatesta, Eleni-Maria A1 Masala, Giovanna A1 Krogh, Vittorio A1 Tumino, Rosario A1 Naccarati, Alessio A1 Mattiello, Amalia A1 Peeters, Petra H A1 Rylander, Charlotta A1 Parr, Christine L A1 Skeie, Guri A1 Weiderpass, Elisabete A1 Quirós, J Ramón A1 Duell, Eric J A1 Dorronsoro, Miren A1 Huerta, José María A1 Ardanaz, Eva A1 Wareham, Nick A1 Khaw, Kay-Tee A1 Travis, Ruth C A1 Key, Tim A1 Stepien, Magdalena A1 Freisling, Heinz A1 Riboli, Elio A1 Bueno-de-Mesquita, H Bas K1 epidemiology K1 juice and nectar K1 pancreatic cancer K1 prevention K1 risk factors K1 soft drinks K1 sugary drinks K1 sweet beverages AB The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa. Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results. YR 2016 FD 2016-08-10 LK http://hdl.handle.net/10668/10352 UL http://hdl.handle.net/10668/10352 LA en DS RISalud RD Apr 6, 2025