RT Journal Article
T1 Nestin(+) cells direct inflammatory cell migration in atherosclerosis.
A1 Del Toro, Raquel
A1 Chèvre, Raphael
A1 Rodríguez, Cristina
A1 Ordóñez, Antonio
A1 Martínez-González, José
A1 Andrés, Vicente
A1 Méndez-Ferrer, Simón
AB Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase ∼30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.
YR 2016
FD 2016-09-02
LK http://hdl.handle.net/10668/10408
UL http://hdl.handle.net/10668/10408
LA en
DS RISalud
RD Apr 7, 2025